盐酸多奈哌齐在老年痴呆治疗中的应用研究(1)
[摘要] 目的 评价盐酸多奈哌齐治疗不同类型老年痴呆的临床疗效、安全性。 方法 选取我院2015年3月～2016年10月期间收治的126例老年痴呆患者作为研究对象，根据病理类型的不同将126例患者分为老年性痴呆组、血管性痴呆组、混合型痴呆组，均给予三组患者常规基础治疗+盐酸多奈哌齐治疗，对比三组患者治疗前、后的MMSE(建议精神状态评价量表)评分、ADL(日常生活能力)评分以及不良反应发生情况和疾病治疗总有效率。 结果 老年性痴呆组患者、混合型痴呆组患者治疗后的MMSE评分、ADL评分均明显升高，与治疗前比较差异有统計学意义(P<0.05)，老年性痴呆组患者上述评分的变化幅度最大。血管性痴呆组患者治疗后的MMSE评分、ADL评分有所升高，与治疗前比较差异有统计学意义(P<0.05)，但低于老年性痴呆组患者、混合型痴呆组(P<0.05)。三组药物不良反应发生率比较差异无统计学意义(P>0.05)。老年性痴呆组的疾病治疗总有效率为96.72%，高于血管性痴呆组的60.00%和混合型痴呆组的80.00%(P<0.05)，血管性痴呆组、混合型痴呆组患者的疾病治疗总有效率比较差异有统计学意义(P<0.05)。 结论 盐酸多奈哌齐治疗老年性血管痴呆可获得显著疗效，治疗混合型痴呆可获得良好疗效，治疗血管性痴呆的疗效较差，但治疗不同类型老年痴呆均具有较高的安全性。
[关键词]老年性痴呆；血管性痴呆；混合型痴呆；盐酸多奈哌齐
[中图分类号] R969 [文献标识码] B [文章编号] 2095-0616(2017)15-186-04
[Abstract] Objective To evaluate the clinical effect and safety of donepezil in the treatment of senile dementia. Methods 126 cases of senile dementia cured in our hospital from March 2015 to October 2016 were selected as the study object. According to the pathological type， the 126 patients were divided into senile dementia group， vascular dementia group and mixed dementia group. All the patients in the three groups were treated with routine basic treatment plus donepezil hydrochloride. Before and after treatment， MMSE (the proposed mental status evaluation scale)， ADL(daily living ability) score， adverse reactions and the total effective rate of treatment of the three groups were compared. Results The scores of MMSE and ADL of patients in senile dementia group and mixed dementia group were significantly increased. Compared with before treatment， there were significant differences (P<0.05). The scores of the above scores were the greatest of the patients in senile dementia group. The scores of MMSE and ADL were increased of patients in vascular dementia group， compared with those before treatment (P<0.05). But it was lower than that of senile dementia group and mixed dementia group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the three groups (P>0.05). The total effective rate of the disease treatment in the senile dementia group was 96.72%， which was higher than 60% in the vascular dementia group and 80% in the mixed dementia group(P<0.05). The total effective rate of disease treatment in patients with vascular dementia and mixed dementia was also significantly different (P<0.05). Conclusion Donepezil hydrochloride is effective in the treatment of senile vascular dementia. Good results can be achieved in the treatment of mixed dementia. The treatment of vascular dementia is less effective， but the treatment of different types of senile dementia has high security., 百拇医药(黄东伟)
[关键词]老年性痴呆；血管性痴呆；混合型痴呆；盐酸多奈哌齐
[中图分类号] R969 [文献标识码] B [文章编号] 2095-0616(2017)15-186-04
[Abstract] Objective To evaluate the clinical effect and safety of donepezil in the treatment of senile dementia. Methods 126 cases of senile dementia cured in our hospital from March 2015 to October 2016 were selected as the study object. According to the pathological type， the 126 patients were divided into senile dementia group， vascular dementia group and mixed dementia group. All the patients in the three groups were treated with routine basic treatment plus donepezil hydrochloride. Before and after treatment， MMSE (the proposed mental status evaluation scale)， ADL(daily living ability) score， adverse reactions and the total effective rate of treatment of the three groups were compared. Results The scores of MMSE and ADL of patients in senile dementia group and mixed dementia group were significantly increased. Compared with before treatment， there were significant differences (P<0.05). The scores of the above scores were the greatest of the patients in senile dementia group. The scores of MMSE and ADL were increased of patients in vascular dementia group， compared with those before treatment (P<0.05). But it was lower than that of senile dementia group and mixed dementia group (P<0.05). There was no significant difference in the incidence of adverse drug reactions between the three groups (P>0.05). The total effective rate of the disease treatment in the senile dementia group was 96.72%， which was higher than 60% in the vascular dementia group and 80% in the mixed dementia group(P<0.05). The total effective rate of disease treatment in patients with vascular dementia and mixed dementia was also significantly different (P<0.05). Conclusion Donepezil hydrochloride is effective in the treatment of senile vascular dementia. Good results can be achieved in the treatment of mixed dementia. The treatment of vascular dementia is less effective， but the treatment of different types of senile dementia has high security., 百拇医药(黄东伟)